Shi Jia Zhuang Kidney Disease Hospital

Reversible phase of fibrosis procedure

 

Continually stimulated by cell factors and growth factors, fibroblasts are in a continual activate proliferous state, and synthesize components of ECM (first synthesize and secrete fibronectin forming mounting structure, then synthesize components of collagen1,3,4,5). In this period, renal inherent cells like mesenteric cells, glomerulus epithelial cells, renal tubular epithelial cells, can change to fibroblasts. Although renal structure and function have changed, the damaged cells also have primary function to some extent.The damaged cells can reverse to normal cells and renew their function by treatment. Actually, blocking the course of damaged cells turning to fibroblasts is the key point in blocking renal fibrosis. If only stop renal cells turning to fibroblasts, the course of renal fibrosis will be blocked. So this period is called reversible stage of fibrosis.Treatment means importance in this period for recovery of kidney disease and reverse of renal failure and great attention should be paid by doctors and patients.