Why are You Haunted by Henoch-Schönlein Purpura with Nephritis

Henoch-Schönlein Purpura with Nephritis (or Purpura Nephritis, Allergic Purpura Nephritis) may occur because people are anaphylactoid to certain medications, bacteria, foods, insect bite, etc. The clinical manifestations include abnormal urine test, acute nephritis syndrome, Nephrotic Syndrome, and Kidney Failure. Hematuria is the most common manifestation. Then why are you haunted by Henoch-Schönlein Purpura with Nephritis?

When some allergic allergens like infection, food, insect bite, etc invade our body, the body has an inherent immune system to fight against these allergens, and there will be series of immune reaction. During the process of immune reaction, immune complex or inflammation can be produced. In normal cases, these immune complexes can be removed with metabolism through blood circulation. However, patients with Henoch-Schönlein Purpura with Nephritis have weak immunity, so the immune complex cannot be eliminated effectively. Since the body still presents immune reaction, more and more immune complex appear over time.

In kidneys, there are special epitopes which attract inflammations. For healthy kidneys, they have function of discharging theses immune complex or inflammation through urine. However, when there appears excessive inflammatory response in the body of Henoch-Schönlein Purpura with Nephritis patient, they cannot be removed timely so they will deposit in glomerular mesangial area. As a result, the renal functional cells of mesangial area can be damaged by these depositions, thus impairing the filtration membrane. Consequently, protein and red blood cells can leak out to the urine. Clinically, patients will present protein in urine and hematuria. If this disease can’t be controlled well, the final result is Kidney Failure. At that time, patient has to receive dialysis or kidney transplant. Therefore, early and effective treatment is very important for the patient.

Immunotherapy can restrain the immune reaction, eliminate immune complex and restore the immune system, thus treating Henoch-Schönlein Purpura with Nephritis thoroughly. For more information, feel free to consult our online service.

• Henoch-Schonlein Purpura Nephritis Causes, Symptoms, Treatment
• Brief Introduction of Henoch-Schonlein Purpura Nephritis
• How Do You Get Purpura Nephritis (Henoch-Schonlein Purpura Nephritis)
• Why are You Haunted by Henoch-Schönlein Purpura with Nephritis
• Why does Purpura Glomerulonephritis Relapse Easily