What's the Causes of Polycystic Kidney

Polycystic Kidney is a kind of genetic nephropathy.

Polycystic Kidney is a kind of genetic nephropathy with birth defect. clinically, according to age of morbidity, medical history of typical inheritance and relative typical performance, doctors can diagnose whether patient has nephropathy or not. Most patients are usually asked whether their close relative or families has the same disease when they are diagnosed the illness of Polycystic Kidney, the reason is lies in its hereditary.

However, though Polycystic Kidney is a kind of genetic nephropathy, but most of Polycystic Kidney patients have symptoms after they are in adult. The morbidity of Polycystic Kidney is high and one person may has this disease in every 200 to 1000 Polycystic Kidney patients, and different sexes of Polycystic Kidney patients have the same probability.

The causes of Polycystic Kidney

As the genetic nephropathy of Polycystic Kidney, the main aetiological agent is the existence of unusual gene in chromosomes. Over 90% of Polycystic Kidney patients with unusual gene on the 16 gene. From patient’s fetus period, this unusual situation had existed and lasted continuously. Most of the Polycystic Kidney patients have clinical symptoms at the age of 40 around.

Nephrotic cysts derive from kidney tubules, it includes proximal tubule and distal tubule. Different original parts with different nature of fluid in the cysts: it derives from proximal tubule, the ingredient of cyst fluid, such as sodion and potassium ion, chlorine, hydrogen, creatinine, urea and so on, is similar to the ingredient in blood plasma; if it derives from distal tubule, fluid in cysts will with low concentration of sodion and potassium ion, but high concentration of hydrogen, creatinine, urea and so on.

To analysis from the view of pathology, the formation of Polycystic Kidney is related to three aspects of factors:

1. The unusual proliferation of intracapsular epithelial cell in glomerular.

Glomerular Intracapsular epithelial cells in Polycystic Kidney patients are immature or in a re-developed status, this is caused by obstruction of regulate and control development of bacteria, it leads the cells in the status of immaturity, thus showing ability of strong proliferation of cells.

2. Unusual transport of inner cells in glomerular capsule.

It shows the subunit combination of sodium, potassium and ATPase which related to cells transport, distribution and changes of expression, abnormal cellular signal transduction and the changes of ion transport channels.

3. Unusual proliferation of Extracellular Matrix.

From the above it can be seen that, due to unusual gene in Polycystic Kidney patient, ischemia of gene can change the development of renal cells and abnormal formation of renal mesenchyme. For patients with protracted course of disease, unusual proliferation of renal cells and deposition of Extracellular Matrix, kidney will appears fibrosis, harden and shrink. Kidney disease will develop into Renal Insufficiency and Uremia, which brings more pains and torments to patients.

Therefore, as to Polycystic Kidney patients, hammering away at this, once the symptoms of Polycystic Kidney exist, people should go to see a doctor for treatment lest delay the golden hour of treatment.

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