Nephrotic Syndrome Relapse: Why Does It Occur Frequently

Why does Nephrotic Syndrome relapse easily and frequently? Many patients often complain that they have received a long period of treatment and the symptoms like massive proteinuria, swelling also disappear at that time. However, even a mild cold may trigger the disease again and ruins all the therapeutic results. This article will give you a clear explanation and it may be helpful for you to decrease and even avoid the Nephrotic Syndrome relapse.

Autoimmunity plays the major role in Nephrotic Syndrome. In healthy condition, when the foreign pathological substances like virus, bacteria and so on invade into our body, the antibodies will be activated by immune system to fight against the pathological substances. Ultimately, the antibodies defeat the antigens so our body can keep in a healthy state and do not present symptoms at all.

However, in some cases, the immune system is activated inappropriately. When the foreign pathological substances invade into body, the antibodies can not defeat them for immune deficiency and disorder. Afterwards, the antibodies encounter and bind to antigens and form very large complexes that have difficulty staying dissolved in the blood. Finally, the immune complexes are brought to kidneys by blood circulation and deposit in glomeruli. The body mounts an inflammatory response to try to remove the immune complexes. When the inflammatory response occurs excessively, it will cause the hypersensitive response. Hypertensive can not clear up the immune complexes, but can damage and impair the glomeruli, leading to Nephrotic Syndrome. In clinic, the patients will present a series of symptoms like swelling, massive proteinuria, low protein level in blood and hyperlipemia.

In the conventional therapies, the patients usually use hormone to treat the symptoms Nephrotic Syndrome and immunosuppressive agents to restrain the abnormal immune inflammatory response. However, as the immune complexes still deposit in glomeruli and their immunity does not improve yet, their disease is susceptible to relapse when the paitents meet inducing factors like colds, infections and so on. That is why Nephrotic Syndrome relapses very frequently.

Therefore, clearing up the immune complexes and blocking the abnormal immune complexes as well as improve the patients’ immunity is the key in the treatment of Nephrotic Syndrome and prevent its relapse.

If you have been tired of the present hormonetheapy and want to find a better one, please consult us on line.

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