What is Hereditary Nephritis

Hereditary Nephritis is a genetic glomerular disease. According to some researches, the incidence of Hereditary Nephritis is approximately 1 in 50,000. If untreated in time, it will progressively develop. Hereditary Nephritis accounts for about 3% of End Stage Renal Failure in children, 3~5% of End Stage Renal Failure in women and a small proportion in men.

Hereditary Nephritis is a primary basement membrane disorder. It arises from mutations in genes encoding several members of the typeⅣ collagen protein family. The disorder damages the glomerular tiny blood vessels in kidney. The glomeruli are responsible for filtering blood to make urine and remove the metabolic wastes from the blood.

In the early stage of Hereditary Nephritis, the patients do not show symptoms. However, with the disease progresses, the glomeruli are destructed over time. As a result, it will lead to blood and protein in urine as well as decrease the renal filtration function. With the kidney function decreases, they excess fluid and wastes products accumulate in body leading to a series of clinical symptoms.

1. Foamy urine for the protein loss in urine.

2. Tea-colored or dark colored urine for red blood cells are lost in urine

3. Decreased or loss of vision and loss of hearing( more common in males)

4. Edema around the eyelids and faces and even edema overall

5. High blood pressure

As it is a hereditary disease, it can progress to End Stage Renal Failure at an early age. In most cases of Hereditary Nephritis, it develops into End Stage Renal Failure between adolescence and age 40. Therefore, it is very urgent for the patients to receive proper treatment as early as possible.

Although the modern gene technique still can not cure Hereditary Nephritis, it is possible for the patients to inhibit the disease progression and avoid End Stage Renal Failure and remove the risk of dialysis and Kidney Transplant completely.

Any help, please email to kidney120@hotmail.com.

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