Immunotherapy for Lupus Nephritis

Lupus Nephritis is a kind of immune kidney disease caused by systemic lupus erythematosus (SLE). SLE can affect multiple organs and systems. When it involves kidneys, it is Lupus Nephritis. Approximately 100% of the patients with SLE have kidney damage in varying degrees and about half of Lupus Nephritis will progress into Renal Failure. Therefore, early inspection and treatment are very essential for the patients with Lupus Nephritis.

How does Lupus Nephritis occur?

When the lupus viruses invade into their bodies, the immune system is activated to fight against the foreign substances. However, the antibodies form pathological immune complexes and deposit in glomeruli. Moreover, the antibodies may bind to antigens in the glomerular basement membrane forming immune complexes in site. For the body’s exclusiveness, it will remove the immune complexes in the glomeruli leading to inflammatory reaction. As the immune system is disordered, it will cause the inflammatory reaction occurs excessively causing damage to renal tissues and cells.

How to treat Lupus Nephritis?

In order to treat Lupus Nephritis, blocking the abnormal inflammatory reaction is the first step. It can prevent the further damage to kidneys temporarily. However, blocking inflammatory is just a transient process. It is not possible for our body to co-exist with the immune complexes.

Then, we need to remove the pathological immune complexes out of body. On this point, Chinese herbal medicine has showed its unique role. The effective integrants can degrade the immune complexes. Afterwards, the degraded immune complexes will be passed out into urine and discharged out of body finally. As a result, the inducement of inflammatory reaction is inhibited thus avoiding the relapse of Lupus Nephritis again.

As the inflammatory reaction has impaired the renal tissues and cells, we need to restore the damaged kidneys to recover the normal renal function. In this step, we need to make use of the differentiation and renewing abilities of stem cells to restore the impaired kidneys. Stem cells are the most primitive cells in body. Under right condition, they can differentiate into new cells to replace the impaired renal cells to function. In this way, the renal function will be improved greatly.

After the above three steps, the patients’ clinical symptoms will relieve obviously, GFR increases, creatinine level reduces, proteinuria disappears and so on. As the above therapies treat Lupus Nephritis from its root causes, the patients have a fundamental recovery and avoid the relapse of the disease.

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