Stem Cells Transplantation Therapy for Diabetic Nephropathy

Stem sells transplantation therapy for diabetic nephropathy

Stem cell is featured by its powerful and continuous self-replication and differentiation abilities. After entering into the body, stem cells will proliferate and differentiate into corresponding cells of damaged renal tissue. By this, there will be more functional cells available and the restoration of tissue function will be possible. In addition, stem cell is the most original cell, which means that they can not be recognized or hunted by immunocyte, so there is no such problems like blood matching.

In terms of treating diabetic nephropathy, stem cells transplantation can really makes a difference. As we have already known, diabetes is caused mainly by the low secretion of insulin or the low sensitivity to insulin of receptors. So , stem cells transplantation therapy aims at repairing damaged Pancreatic Island and islet beta cells to improve the secretion of insulin, at the same time, stem cells improve the insulin sensitivity of receptors.

Therapeutical mechanism

Firstly, stem cells can directly repair the Pancreatic Island and improve the generation of islet βcells.

Secondly, stem cells can repair damaged islet beta cells directly and enhance the secretion of insulin.

Thirdly, stem cells can repair other related cells that can also secrete insulin. There are other tissue cells that can also secrete insulin, so the repairing of these cells will surely promote the available insulin within the body.

Fourthly, stem cells can also repair insulin receptor which exist in cell membranes, and repair the glycoprotein transporting receptors, which improves their sensitivity to stimulation of insulin. Stem cell can also enhance the combination of insulin and receptors, as well as the combination of transshipment glycoprotein and glucose. The inhibition of insulin resistance will be realized.

Fifthly, after entering into the body, stem cells stimulate vascular endothelial growth factors and facilitate them to proliferate and generate new blood vessels. Partial blood circulation obstacles will be removed and the sufficient supplement of blood and oxygen accelerates the restoration of renal function.

Sixthly, stem cells will rebuild the immune system and thus promote cellular immunity and humoral immunity and thus improve the whole body pathogen-resistance ability.

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